DNA and RNA Binders, From Small Molecules to Drugs Volume 1

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Results for DNA and RNA Binders, From Small Molecules to Drugs Volume 1

1. Front Matter - Wiley Online Library

RNA Binders. M. Demeunynck, C. Bailly,. W. D. Wilson (Eds.) Small Molecule
DNA and RNA Binders: From Synthesis to Nucleic Acid Complexes. Edited by M.
... Volume 1. Preface xix. Contributors xxi. 1. Forty Years On. 1.
Tags:DNA and RNA Binders, From Small Molecules to Drugs Volume 1

2. "Front Matter". In: Small Molecule DNA and RNA Binders

Ligands for TAR RNA. 63. 4.5.1. TAR RNA Bulge Binders. 63. 4.5.2. Targeting
Multiple Sites in TAR RNA. 65. 4.5.3. Targeting RNA with Peptidomimetic
Oligomers. 66. 4.5.3.1 Backbone modification. 66. 4.5.3
Tags:DNA and RNA Binders, From Small Molecules to Drugs Volume 1

3. Strong and weak hydrogen bonds in drug-DNA - Springer Link

The forces that dominate small molecule minor groove-binding interactions are
electrostatic, van der Waals, hydrophobic and hydrogen bonding. A crucial
requirement for the ligand is a crescent shape that is complementary to the Tags:DNA and RNA Binders, From Small Molecules to Drugs Volume 1

4. DESIGN AND SYNTHESIS OF NOVEL DNA BINDERS

some model compounds. Also, preliminary antiproliferative activity and other
biological properties of these compounds are currently under investigation and
will be presented. ____. [1] Demeunynck, M.; Bailly, C.; Wilson, W.D. DNA and

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5. interaction of small molecules with nucleic acid targets: from rna

mechanism of the target. The need for new small molecules that target nucleic
acids is evident. However, designing a novel drug to bind to DNA or RNA
requires a detailed understanding of exactly what binding en
Tags:DNA and RNA Binders, From Small Molecules to Drugs Volume 1

6. ENERGETICS OF DRUG-DNA INTERACTIONS 373 - ScienceDirect

binding directly to DNA, and subsequently inhibiting gene expression or
replication by interfering with the enzymes that catalyze these functions. 1-5. The
structures of a ... laboratories is the rational design of small molecul
Tags:DNA and RNA Binders, From Small Molecules to Drugs Volume 1

7. Altered sequence specificity identified from a library of DNA-binding

their expression using small molecules has major implica- tions for medicine, as
... sequence-selective DNA-binding agents have been achieved [1,4–12].
Polyamides have been developed that exhibit a one-to-one c
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8. Rational Design of Small Molecules Targeting RNA - American

Oct 27, 2016 ... provide in vivo active compounds? 17. What are major challenges in developing
small molecules targeting RNA? (possible multiple correct answers) ... (2002), 1,
727. The Human Genome/Encode Projects –
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9. Defining RNA–Small Molecule Affinity - ACS Publications

Mar 6, 2017 ... ABSTRACT: RNA drug targets are pervasive in cells, but methods to design small
molecules that target them are sparse. .... Global Analysis of Selected RNA Motif−
Small. Molecule Interactions a compound
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10. intercalating and minor groove binding drugs

DNA minor groove binders (MGBs), one of the most widely studied type of small
molecules (4), can be grouped into two functional groups: 1) substances that
cause ..... C, Wilson WD, editors. DNA and RNA binders: fro
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